Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 9/20 | 0.45 |
| ▸ | GART | P22102 | 2/20 | 0.45 |
| ▸ | ATIC | P31939 | 1/20 | 0.45 |
| ▸ | SLC19A1 | P41440 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375155 | 0.91 | TYMS (0.68) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL9853745 | 0.89 | TYMS (0.71) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL440460 | 0.88 | TYMS (0.70) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL30293737 | 0.88 | TYMS (0.70) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL2577686 | 0.88 | TYMS (0.70) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL6389507 | 0.87 | TYMS (0.69) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL7758365 | 0.87 | TYMS (0.68) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL30887631 | 0.87 | TYMS (0.68) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL30076811 | 0.85 | TYMS (0.65) | TYMSKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL8003250 | 0.85 | TYMS (0.65) | TYMSKDM4EMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10876003-B2 | Class of stable heptamethine cyanine fluorophores and biomedical applications thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2020-12-29 | — | — | US | disclosed |
| US-20190225811-A1 | CLASS OF STABLE HEPTAMETHINE CYANINE FLUOROPHORES AND BIOMEDICAL APPLICATIONS THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2019-07-25 | — | — | US | disclosed |
| US-10280307-B2 | Class of stable heptamethine cyanine fluorophores and biomedical applications thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-05-07 | — | — | US | disclosed |
| US-20180273758-A1 | NEW CLASS OF STABLE HEPTAMETHINE CYANINE FLUOROPHORES AND BIOMEDICAL APPLICATIONS THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN (US) | 2018-09-27 | — | — | US | disclosed |
| WO-2016072984-A1 | A NEW CLASS OF STABLE HEPTAMETHINE CYANINE FLUOROPHORES AND BIOMEDICAL APPLICATIONS THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280307-B2 | Class of stable heptamethine cyanine fluorophores and biomedical applications thereof | C5, CYP4F8, CYP4F3 | TYMS 1368/4885KDM4E 616/4885MEN1 167/4885 |
| US-20190225811-A1 | CLASS OF STABLE HEPTAMETHINE CYANINE FLUOROPHORES AND BIOMEDICAL APPLICATIONS THEREOF | C5, CYP4F8, CYP4F3 | TYMS 1368/4885KDM4E 616/4885MEN1 167/4885 |
| US-10876003-B2 | Class of stable heptamethine cyanine fluorophores and biomedical applications thereof | C5, CYP4F8, CYP4F3 | TYMS 1368/4885KDM4E 616/4885MEN1 167/4885 |
| US-20180273758-A1 | NEW CLASS OF STABLE HEPTAMETHINE CYANINE FLUOROPHORES AND BIOMEDICAL APPLICATIONS THEREOF | CYP4F8, C5, CYP4F3 | TYMS 1268/4885KDM4E 825/4885MEN1 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.