Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.58 |
| ▸ | HTR6 | P50406 | 11/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1046149 | 0.91 | BRD4 (0.51) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL1050312 | 0.84 | BRD4 (0.64) | BRD4HTR6METCYP2C19 | |
| SCHEMBL1799967 | 0.84 | BRD4 (0.67) | BRD4HTR6METCYP2C19 | |
| SCHEMBL1773389 | 0.84 | HTR6 (0.51) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL1043519 | 0.84 | BRD4 (0.58) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL1266871 | 0.84 | BRD4 (0.58) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL1887325 | 0.84 | BRD4 (0.58) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL1268099 | 0.81 | BRD4 (0.58) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL13306676 | 0.81 | BRD4 (0.55) | BRD4HTR6DRD2HTR2AHTR7 | |
| SCHEMBL3348969 | 0.81 | BRD4 (0.55) | BRD4HTR6DRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338452-B2 | Raf inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20110110889-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Bio Pharma Inc. (US) | 2011-05-12 | — | — | US | disclosed |
| EP-2265608-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009111278-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110110889-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | BRD4 3329/4885HTR6 4804/4885DRD2 4835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.