Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 2/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.42 |
| ▸ | VCP | P55072 | 6/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9885082 | 1.00 | HRH4 (0.49) | HRH4PAK4PAK1VCPCCNK | |
| SCHEMBL9885067 | 0.88 | HRH4 (0.49) | HRH4VCPKDM4EMAPK1CDK1 | |
| SCHEMBL16790179 | 0.88 | HRH4 (0.49) | HRH4VCPKDM4EMAPK1CDK1 | |
| SCHEMBL13668600 | 0.88 | HRH4 (0.49) | HRH4VCPKDM4EMAPK1CDK1 | |
| SCHEMBL9884988 | 0.84 | HRH4 (0.45) | HRH4PAK4PAK1CDK9CCNT1 | |
| SCHEMBL13667224 | 0.82 | VCP (0.57) | VCP | |
| SCHEMBL17639929 | 0.81 | HRH4 (0.44) | HRH4VCPCDK9CDK2CCNT1 | |
| SCHEMBL17639934 | 0.81 | HRH4 (0.44) | HRH4VCPCDK9CDK2CCNT1 | |
| SCHEMBL13683502 | 0.79 | HRH4 (0.46) | HRH4VCPCCNKCDK9KDM4E | |
| SCHEMBL9885050 | 0.79 | HRH4 (0.46) | HRH4VCPCCNKCDK9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890703-B1 | PYRIMIDINE COMPOUNDS AS CHEMOKINE RECEPTORS INHIBITORS | TAIGEN BIOTECHNOLOGY CO LTD (TW) | 2016-05-11 | — | — | EP | disclosed |