Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17067817 | 0.78 | KDM4E (0.42) | ALDH1A1KDM4EUSP2 | |
| SCHEMBL30724578 | 0.69 | LMNA (0.35) | ALDH1A1LMNAKMT2AHTTGAA | |
| SCHEMBL17787710 | 0.68 | LMNA (0.34) | ALDH1A1LMNAKMT2AHTTGAA | |
| SCHEMBL17655487 | 0.67 | MAPT (0.38) | ALDH1A1LMNAKMT2AHTTMEN1 | |
| SCHEMBL15647482 | 0.64 | LMNA (0.34) | ALDH1A1LMNAKMT2AHTTGAA | |
| SCHEMBL883891 | 0.64 | LMNA (0.34) | ALDH1A1LMNAKMT2AHTTGAA | |
| SCHEMBL30425332 | 0.63 | LMNA (0.36) | ALDH1A1LMNAKMT2AHTTGAA | |
| SCHEMBL19027031 | 0.62 | MAPT (0.35) | LMNAKMT2AHTTGAAMEN1 | |
| SCHEMBL19027124 | 0.62 | GAA (0.40) | ALDH1A1KMT2AGAAMEN1MAPT | |
| SCHEMBL229286 | 0.60 | LMNA (0.57) | ALDH1A1LMNAKMT2AHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611777-B1 | N-(4-{[PYRIDIN-3-YL-METHYL)CARBAMOYL]AMINO}BENZENE-SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER | FORMA TM LLC (US) | 2016-05-11 | — | — | EP | disclosed |