Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2239879 | 0.92 | MCL1 (0.37) | ATMNR1H3HCRTR2BCL2MCL1 | |
| SCHEMBL2239875 | 0.92 | MCL1 (0.37) | ATMNR1H3HCRTR2BCL2MCL1 | |
| SCHEMBL176959 | 0.92 | NR1H3 (0.37) | ATMNR1H3HCRTR2ALDH1A1MAOB | |
| SCHEMBL176906 | 0.92 | ATM (0.39) | ATMNR1H3HCRTR2ALDH1A1KDM4E | |
| SCHEMBL2240314 | 0.92 | ATM (0.39) | ATMNR1H3HCRTR2ALDH1A1KDM4E | |
| SCHEMBL177178 | 0.89 | ATM (0.40) | ATMNR1H3HCRTR2ALDH1A1MAOB | |
| SCHEMBL2305486 | 0.84 | MCL1 (0.38) | ATMBCL2MCL1 | |
| SCHEMBL2305489 | 0.84 | MCL1 (0.38) | ATMBCL2MCL1 | |
| SCHEMBL2239287 | 0.84 | NR1H3 (0.35) | NR1H3HCRTR2MAOBBCL2MCL1 | |
| SCHEMBL2239291 | 0.84 | NR1H3 (0.35) | NR1H3HCRTR2MAOBBCL2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2345644-A1 | INDAZOLE COMPOUND | Asahi Kasei Pharma Corporation (JP) | 2011-07-20 | — | — | EP | disclosed |