Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774779 | 0.87 | MAPT (0.45) | LMNARXFP1MAPTMEN1KMT2A | |
| SCHEMBL1775201 | 0.86 | MEN1 (0.42) | LMNARXFP1MAPTMEN1KMT2A | |
| SCHEMBL1773901 | 0.85 | MAPT (0.62) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL27745413 | 0.84 | MAPT (0.43) | LMNARXFP1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1773447 | 0.84 | MEN1 (0.52) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4701575 | 0.84 | MAPT (0.42) | LMNARXFP1MAPTAHRMEN1 | |
| SCHEMBL2174057 | 0.83 | MAPT (0.53) | LMNARXFP1MAPTMEN1KMT2A | |
| SCHEMBL1773844 | 0.83 | LMNA (0.49) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1773691 | 0.82 | MAPT (0.44) | LMNARXFP1MAPTAHRMEN1 | |
| SCHEMBL1773998 | 0.81 | MAPT (0.45) | LMNARXFP1MAPTAHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966212-B1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2015-05-13 | — | — | EP | disclosed |
| US-7943608-B2 | Diazepinoes | MERCK PATENT GMBH (DE) | 2011-05-17 | — | — | US | disclosed |
| CN-101341151-A | Diazepinones | MERCK PATENT GMBH (DE) | 2009-01-07 | — | — | CN | disclosed |
| US-20080318934-A1 | Diazepinoes | MERCK PATENT GESELLSCHAFT (DE) | 2008-12-25 | — | — | US | disclosed |
| EP-1966212-A1 | DIAZEPINONES | Merck Patent GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079826-A1 | DIAZEPINONES | MERCK PATENT GMBH (DE) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318934-A1 | Diazepinoes | CDK1, MAP3K11, MAP3K1 | LMNA 1800/4885RXFP1 3105/4885MAPT 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.