Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18373834 | 0.89 | MAPT (0.33) | CYP3A4FGFR3CYP2C19FGFR1 | |
| SCHEMBL17740761 | 0.87 | FGFR1 (0.46) | FGFR3FGFR1 | |
| SCHEMBL17736231 | 0.86 | FGFR1 (0.33) | CYP3A4FGFR3CYP2C19FGFR1 | |
| SCHEMBL16659420 | 0.86 | FGFR1 (0.33) | CYP3A4FGFR3CYP2C19FGFR1 | |
| SCHEMBL16665323 | 0.83 | FGFR1 (0.34) | CYP3A4FGFR3CYP2C19FGFR1 | |
| SCHEMBL19633582 | 0.78 | FGFR1 (0.44) | CYP3A4FGFR3CYP2C19FGFR1 | |
| SCHEMBL17736237 | 0.78 | FGFR1 (0.43) | CYP3A4FGFR3CYP2C19FGFR1 | |
| SCHEMBL19633353 | 0.78 | FGFR1 (0.44) | CYP3A4FGFR3CYP2C19FGFR1 | |
| SCHEMBL19633339 | 0.78 | FGFR1 (0.45) | CYP3A4FGFR3CYP2C19FGFR1 | |
| SCHEMBL16665243 | 0.78 | FGFR1 (0.36) | CYP3A4FGFR3CYP2C19FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730931-B2 | Pyrimidine FGFR4 inhibitors | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-15 | — | — | US | disclosed |
| US-20170007601-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-01-12 | — | — | US | disclosed |
| US-9434697-B2 | Pyrimidine FGFR4 inhibitors | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-09-06 | — | — | US | disclosed |
| US-20160130237-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130237-A1 | PYRIMIDINE FGFR4 INHIBITORS | FGFR4, FGFR1, FGFR3 | CYP3A4 929/4885FGFR3 3/4885CYP2C19 1975/4885 |
| US-20170007601-A1 | PYRIMIDINE FGFR4 INHIBITORS | FGFR4, FGFR1, FGFR3 | CYP3A4 929/4885FGFR3 3/4885CYP2C19 1975/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.