Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | INSR | P06213 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | FYN | P06241 | 2/20 | 0.31 |
| ▸ | YES1 | P07947 | 2/20 | 0.31 |
| ▸ | LYN | P07948 | 2/20 | 0.31 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | ROS1 | P08922 | 2/20 | 0.31 |
| ▸ | KIT | P10721 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | FLT1 | P17948 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17736231 | 0.90 | FGFR1 (0.33) | FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16659423 | 0.89 | FGFR1 (0.32) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL16665233 | 0.87 | FGFR1 (0.48) | FGFR1FGFR3FGFR4FGFR2 | |
| SCHEMBL17740760 | 0.86 | CYP3A4 (0.33) | FGFR1FGFR3CYP3A4CYP2C19 | |
| SCHEMBL16665323 | 0.84 | FGFR1 (0.34) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL19633582 | 0.80 | FGFR1 (0.44) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL17736237 | 0.80 | FGFR1 (0.43) | FGFR1FGFR3CYP3A4CYP2C19JAK2 | |
| SCHEMBL19633353 | 0.80 | FGFR1 (0.44) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL20844611 | 0.80 | FGFR1 (0.47) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 | |
| SCHEMBL19633339 | 0.80 | FGFR1 (0.45) | FGFR1FGFR3CYP3A4CYP2C19FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |