Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 20/20 | 0.70 |
| ▸ | MMP2 | P08253 | 17/20 | 0.70 |
| ▸ | MMP9 | P14780 | 10/20 | 0.70 |
| ▸ | MMP3 | P08254 | 5/20 | 0.70 |
| ▸ | MMP1 | P03956 | 3/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365127 | 0.86 | ADAM10 (0.78) | ADAM10MMP2MMP9MMP3MMP1 | |
| SCHEMBL1364303 | 0.86 | ADAM10 (0.78) | ADAM10MMP2MMP9MMP3MMP1 | |
| SCHEMBL1363621 | 0.84 | ADAM10 (0.79) | ADAM10MMP2MMP9MMP3MMP1 | |
| SCHEMBL1364163 | 0.84 | ADAM10 (0.76) | ADAM10MMP2MMP9MMP3MMP1 | |
| SCHEMBL1363774 | 0.84 | ADAM10 (0.75) | ADAM10MMP2MMP9MMP3MMP1 | |
| SCHEMBL1366743 | 0.84 | ADAM10 (0.76) | ADAM10MMP2MMP9MMP3MMP1 | |
| SCHEMBL1363752 | 0.84 | ADAM10 (0.75) | ADAM10MMP2MMP9MMP3MMP1 | |
| SCHEMBL1364086 | 0.83 | ADAM10 (0.78) | ADAM10MMP2MMP9MMP3MMP1 | |
| SCHEMBL1366594 | 0.83 | ADAM10 (1.00) | ADAM10MMP2MMP9MMP3MMP1 | |
| SCHEMBL1364799 | 0.83 | ADAM10 (1.00) | ADAM10MMP2MMP9MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3020402-A1 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | Incyte Holdings Corporation (US) | 2016-05-18 | — | — | EP | claimed |