SCHEMBL17745596

SCHEMBL17745596

CCn1cc(OC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2F)c(=O)n(-c2ccc(F)cc2)c1=O

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MET P08581 19/20 0.69
AXL P30530 11/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17745530 0.93 MET (0.80) METAXL
SCHEMBL17745567 0.90 MET (0.64) METAXL
SCHEMBL17745599 0.90 MET (0.72) METAXL
SCHEMBL17745533 0.90 MET (0.80) METAXL
SCHEMBL17745648 0.89 MET (0.81) METAXL
SCHEMBL16089998 0.89 MET (0.86) METAXL
SCHEMBL17745601 0.88 MET (0.74) METAXL
SCHEMBL17745574 0.88 MET (0.81) METAXL
SCHEMBL17745571 0.87 AXL (0.81) METAXL
SCHEMBL17745573 0.87 MET (0.68) METAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2780338-B1 URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS IGNYTA INC (US) 2016-11-09 EP claimed