Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604271 | 1.00 | HRH4 (0.54) | HRH4HTR3AROCK1PARP1KCNH2 | |
| SCHEMBL606652 | 0.96 | HRH4 (0.56) | HRH4HTR3AROCK1PARP1KCNH2 | |
| SCHEMBL1774220 | 0.96 | HRH4 (0.56) | HRH4HTR3AROCK1PARP1KCNH2 | |
| SCHEMBL606677 | 0.96 | HRH4 (0.56) | HRH4HTR3AROCK1PARP1KCNH2 | |
| SCHEMBL18601617 | 0.83 | HRH4 (0.55) | HRH4HTR3AROCK1 | |
| SCHEMBL1773449 | 0.83 | HRH4 (0.55) | HRH4HTR3AROCK1 | |
| SCHEMBL1781039 | 0.82 | HRH4 (0.44) | HRH4KCNH2HRH3 | |
| SCHEMBL18601593 | 0.80 | HRH4 (0.52) | HRH4HTR3AROCK1PARP1KCNH2 | |
| SCHEMBL606483 | 0.80 | HRH4 (0.52) | HRH4HTR3AROCK1PARP1HRH3 | |
| SCHEMBL18601596 | 0.80 | HRH4 (0.52) | HRH4HTR3AROCK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |