Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774130 | 1.00 | HRH4 (0.52) | HRH4HTR3ANUDT1ROCK1DPP4 | |
| SCHEMBL604438 | 0.88 | HRH4 (0.50) | HRH4HTR3AROCK1 | |
| SCHEMBL606271 | 0.88 | HRH4 (0.50) | HRH4HTR3AROCK1 | |
| SCHEMBL1774401 | 0.88 | HRH4 (0.50) | HRH4HTR3AROCK1 | |
| SCHEMBL18601614 | 0.87 | HRH4 (0.49) | HRH4HTR3AROCK1 | |
| SCHEMBL1774682 | 0.87 | HRH4 (0.49) | HRH4HTR3AROCK1 | |
| SCHEMBL1775152 | 0.87 | HRH4 (0.51) | HRH4HTR3AROCK1PARP1 | |
| SCHEMBL1774952 | 0.87 | HRH4 (0.51) | HRH4HTR3AROCK1PARP1 | |
| SCHEMBL1775069 | 0.87 | HRH4 (0.51) | HRH4HTR3AROCK1PARP1 | |
| SCHEMBL1774549 | 0.86 | HRH4 (0.48) | HRH4HTR3AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |