Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17749242 | 1.00 | HDAC8 (0.36) | HDAC8EPHX2 | |
| SCHEMBL17747018 | 0.84 | HDAC8 (0.43) | HDAC8 | |
| SCHEMBL17746996 | 0.84 | HDAC8 (0.43) | HDAC8 | |
| SCHEMBL17746994 | 0.84 | HDAC8 (0.43) | HDAC8 | |
| SCHEMBL17747020 | 0.84 | HDAC8 (0.43) | HDAC8 | |
| SCHEMBL17749224 | 0.80 | EPHX2 (0.40) | HDAC8EPHX2 | |
| SCHEMBL20009571 | 0.78 | HDAC8 (0.35) | HDAC8 | |
| SCHEMBL17746953 | 0.76 | NOD1 (0.44) | HDAC8 | |
| SCHEMBL17746956 | 0.76 | NOD1 (0.44) | HDAC8 | |
| SCHEMBL17746938 | 0.76 | NOD1 (0.44) | HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218392-A1 | MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS | Bristol-Myers Squibb Company (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077518-A1 | MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-05-19 | — | — | WO | disclosed |