Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 12/20 | 1.00 |
| ▸ | CECR2 | Q9BXF3 | 6/20 | 0.77 |
| ▸ | TAF1 | P21675 | 4/20 | 0.74 |
| ▸ | BRD4 | O60885 | 4/20 | 0.66 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.63 |
| ▸ | BRD2 | P25440 | 1/20 | 0.63 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.63 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.63 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.63 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.63 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.63 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.63 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30073209 | 1.00 | BRD9 (1.00) | BRD9CECR2TAF1BRD4TRIM24 | |
| SCHEMBL17749688 | 1.00 | BRD9 (1.00) | BRD9CECR2TAF1BRD4TRIM24 | |
| SCHEMBL17758608 | 0.92 | BRD9 (1.00) | BRD9CECR2TAF1BRD4TRIM24 | |
| SCHEMBL30073396 | 0.92 | BRD9 (1.00) | BRD9CECR2TAF1BRD4TRIM24 | |
| SCHEMBL17749874 | 0.87 | CECR2 (1.00) | BRD9CECR2TAF1BRD4 | |
| SCHEMBL17749875 | 0.87 | CECR2 (1.00) | BRD9CECR2TAF1BRD4 | |
| SCHEMBL30073235 | 0.87 | BRD9 (1.00) | BRD9CECR2TAF1BRD4 | |
| SCHEMBL17749775 | 0.87 | BRD9 (1.00) | BRD9CECR2TAF1BRD4 | |
| SCHEMBL17749803 | 0.87 | BRD9 (1.00) | BRD9CECR2TAF1BRD4 | |
| SCHEMBL29482192 | 0.86 | BRD9 (0.98) | BRD9CECR2TAF1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077378-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |