Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 1.00 |
| ▸ | CECR2 | Q9BXF3 | 9/20 | 0.85 |
| ▸ | BRD9 | Q9H8M2 | 7/20 | 0.85 |
| ▸ | TAF1 | P21675 | 5/20 | 0.85 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.70 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.70 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.70 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.70 |
| ▸ | EP300 | Q09472 | 1/20 | 0.70 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.70 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.70 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.70 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17749687 | 1.00 | BRD4 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL17749670 | 0.92 | BRD4 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL30073311 | 0.92 | BRD4 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL17749838 | 0.92 | BRD4 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL17749833 | 0.88 | BRD4 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL29482212 | 0.88 | BRD4 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL17748956 | 0.88 | CECR2 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL17749708 | 0.87 | CECR2 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL17748869 | 0.86 | BRD9 (1.00) | BRD4CECR2BRD9TAF1TRIM24 | |
| SCHEMBL17749840 | 0.84 | BRD4 (1.00) | BRD4CECR2BRD9TAF1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077378-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |