Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 14/20 | 1.00 |
| ▸ | BRD4 | O60885 | 8/20 | 1.00 |
| ▸ | BRD7 | Q9NPI1 | 3/20 | 1.00 |
| ▸ | BRD2 | P25440 | 2/20 | 1.00 |
| ▸ | BRD3 | Q15059 | 2/20 | 1.00 |
| ▸ | BRDT | Q58F21 | 2/20 | 1.00 |
| ▸ | KAT2A | Q92830 | 2/20 | 1.00 |
| ▸ | GABBR2 | O75899 | 1/20 | 1.00 |
| ▸ | EP300 | Q09472 | 1/20 | 1.00 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 1.00 |
| ▸ | CREBBP | Q92793 | 1/20 | 1.00 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 1.00 |
| ▸ | CECR2 | Q9BXF3 | 3/20 | 0.70 |
| ▸ | TAF1 | P21675 | 1/20 | 0.70 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30073326 | 1.00 | BRD9 (1.00) | BRD9BRD4BRD7BRD2BRD3 | |
| SCHEMBL17749889 | 1.00 | BRD9 (1.00) | BRD9BRD4BRD7BRD2BRD3 | |
| SCHEMBL17758443 | 0.88 | BRD4 (0.79) | BRD9BRD4BRD7BRD2BRD3 | |
| SCHEMBL30073297 | 0.86 | BRD9 (1.00) | BRD9BRD4BRD7BRD2BRD3 | |
| SCHEMBL19640321 | 0.86 | BRD9 (1.00) | BRD9BRD4BRD7BRD2BRD3 | |
| SCHEMBL17749698 | 0.85 | BRD9 (1.00) | BRD9BRD4BRD7BRD2BRD3 | |
| SCHEMBL19640343 | 0.83 | BRD9 (1.00) | BRD9BRD4BRD7BRD2BRD3 | |
| SCHEMBL24363764 | 0.79 | BRD9 (0.79) | BRD9BRD4BRD7BRD2BRD3 | |
| SCHEMBL24364270 | 0.79 | BRD4 (0.75) | BRD9BRD4BRD7BRD2BRD3 | |
| SCHEMBL30073548 | 0.78 | BRD9 (0.81) | BRD9BRD4BRD7BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077378-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |