Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.79 |
| ▸ | BRD9 | Q9H8M2 | 9/20 | 0.79 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.79 |
| ▸ | BRD2 | P25440 | 1/20 | 0.79 |
| ▸ | EP300 | Q09472 | 1/20 | 0.79 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.79 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.79 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.79 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.79 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.79 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.79 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.79 |
| ▸ | CECR2 | Q9BXF3 | 5/20 | 0.76 |
| ▸ | TAF1 | P21675 | 3/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30073326 | 0.88 | BRD9 (1.00) | BRD4BRD9GABBR2BRD2EP300 | |
| SCHEMBL17749889 | 0.88 | BRD9 (1.00) | BRD4BRD9GABBR2BRD2EP300 | |
| SCHEMBL17749782 | 0.88 | BRD9 (1.00) | BRD4BRD9GABBR2BRD2EP300 | |
| SCHEMBL19640343 | 0.86 | BRD9 (1.00) | BRD4BRD9GABBR2BRD2EP300 | |
| SCHEMBL17749707 | 0.79 | BRD4 (1.00) | BRD4BRD9GABBR2BRD2EP300 | |
| SCHEMBL17749706 | 0.79 | BRD4 (1.00) | BRD4BRD9GABBR2BRD2EP300 | |
| SCHEMBL17749827 | 0.73 | CECR2 (1.00) | BRD4BRD9BRD2BRD3BRDT | |
| SCHEMBL17749830 | 0.73 | CECR2 (1.00) | BRD4BRD9BRD2BRD3BRDT | |
| SCHEMBL19640321 | 0.73 | BRD9 (1.00) | BRD4BRD9GABBR2BRD2EP300 | |
| SCHEMBL30073297 | 0.73 | BRD9 (1.00) | BRD4BRD9GABBR2BRD2EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077378-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |