Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 1.00 |
| ▸ | CECR2 | Q9BXF3 | 6/20 | 0.80 |
| ▸ | BRD9 | Q9H8M2 | 8/20 | 0.71 |
| ▸ | TAF1 | P21675 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17749796 | 1.00 | BRD4 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL17749874 | 0.89 | CECR2 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL17749875 | 0.89 | CECR2 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL19640295 | 0.83 | BRD4 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL19640296 | 0.83 | BRD4 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL30073340 | 0.83 | BRD4 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL17749682 | 0.83 | BRD9 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL30073223 | 0.83 | BRD9 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL17749815 | 0.83 | BRD9 (1.00) | BRD4CECR2BRD9TAF1 | |
| SCHEMBL17749785 | 0.81 | BRD4 (1.00) | BRD4CECR2BRD9TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | claimed |
| WO-2016077378-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | claimed |
| EP-3218375-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077378-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |