Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.73 |
| ▸ | BRD9 | Q9H8M2 | 7/20 | 0.70 |
| ▸ | CECR2 | Q9BXF3 | 5/20 | 0.62 |
| ▸ | TAF1 | P21675 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17749887 | 1.00 | BRD4 (0.73) | BRD4BRD9CECR2TAF1 | |
| SCHEMBL30073340 | 0.84 | BRD4 (1.00) | BRD4BRD9CECR2TAF1 | |
| SCHEMBL17749742 | 0.83 | BRD9 (1.00) | BRD4BRD9CECR2TAF1 | |
| SCHEMBL30073291 | 0.83 | BRD9 (1.00) | BRD4BRD9CECR2TAF1 | |
| SCHEMBL17749745 | 0.83 | BRD9 (1.00) | BRD4BRD9CECR2TAF1 | |
| SCHEMBL24363703 | 0.78 | BRD4 (0.71) | BRD4BRD9CECR2TAF1 | |
| SCHEMBL19640306 | 0.77 | CECR2 (1.00) | BRD4BRD9CECR2TAF1 | |
| SCHEMBL19640308 | 0.77 | CECR2 (1.00) | BRD4BRD9CECR2TAF1 | |
| SCHEMBL30073278 | 0.77 | CECR2 (1.00) | BRD4BRD9CECR2TAF1 | |
| SCHEMBL19640299 | 0.75 | BRD9 (1.00) | BRD4BRD9CECR2TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077378-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |