Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.43 |
| ▸ | HTR2A | P28223 | 7/20 | 0.43 |
| ▸ | HTR7 | P34969 | 7/20 | 0.43 |
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | GUSB | P08236 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1775274 | 0.99 | HTR6 (0.43) | HTR6HTR2AHTR7DRD2GUSB | |
| SCHEMBL1774740 | 0.94 | GUSB (0.45) | HTR6HTR2AHTR7DRD2GUSB | |
| Hydrochloric Acid SCHEMBL1775770 | 0.94 | GUSB (0.45) | HTR6HTR2AHTR7DRD2GUSB | |
| SCHEMBL1776711 | 0.85 | HTR6 (0.43) | HTR6HTR2AHTR7DRD2GUSB | |
| Hydrochloric Acid SCHEMBL1776453 | 0.84 | HTR6 (0.43) | HTR6HTR2AHTR7DRD2GUSB | |
| SCHEMBL1774492 | 0.83 | GUSB (0.54) | HTR6HTR2AHTR7DRD2GUSB | |
| Hydrochloric Acid SCHEMBL1775163 | 0.82 | GUSB (0.53) | HTR6HTR2AHTR7DRD2GUSB | |
| SCHEMBL1775796 | 0.82 | SLC2A1 (0.48) | HTR6HTR2AHTR7DRD2 | |
| SCHEMBL1776724 | 0.81 | GUSB (0.57) | HTR6HTR7DRD2GUSB | |
| SCHEMBL1776417 | 0.81 | HTR6 (0.48) | HTR6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |