Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775069 | 1.00 | HRH4 (0.51) | HRH4HTR3AROCK1PARP1DHFR | |
| SCHEMBL1774952 | 1.00 | HRH4 (0.51) | HRH4HTR3AROCK1PARP1DHFR | |
| SCHEMBL1774889 | 0.96 | HRH4 (0.50) | HRH4HTR3AROCK1 | |
| SCHEMBL1775210 | 0.96 | HRH4 (0.50) | HRH4HTR3AROCK1 | |
| SCHEMBL1774130 | 0.87 | HRH4 (0.52) | HRH4HTR3AROCK1PARP1 | |
| SCHEMBL18601593 | 0.87 | HRH4 (0.52) | HRH4HTR3AROCK1PARP1 | |
| SCHEMBL604438 | 0.85 | HRH4 (0.50) | HRH4HTR3AROCK1 | |
| SCHEMBL606271 | 0.85 | HRH4 (0.50) | HRH4HTR3AROCK1 | |
| SCHEMBL1774401 | 0.85 | HRH4 (0.50) | HRH4HTR3AROCK1 | |
| SCHEMBL18601614 | 0.84 | HRH4 (0.49) | HRH4HTR3AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| US-20070185075-A1 | Pyrimidine derivatives | PFIZER LIMITED | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185075-A1 | Pyrimidine derivatives | TYMS, DPYD, TYMP | HRH4 184/4885HTR3A 1577/4885ROCK1 3749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.