Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 5/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 4/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15031958 | 0.88 | KIT (0.46) | PDGFRBPDGFRAKITFYNALDH1A1 | |
| SCHEMBL10436281 | 0.85 | KIT (0.59) | PDGFRBPDGFRAKITFYNHTR2C | |
| SCHEMBL16541913 | 0.84 | KIT (0.58) | PDGFRBPDGFRAKITFYNHTR2C | |
| SCHEMBL12268833 | 0.82 | NFE2L2 (0.44) | PDGFRBPDGFRAHTR2CPTGS1NFE2L2 | |
| SCHEMBL17752371 | 0.81 | PDGFRB (0.46) | PDGFRBPDGFRAKITFYNHTR2C | |
| SCHEMBL15031948 | 0.79 | PDGFRB (0.44) | PDGFRBPDGFRAKITFYN | |
| SCHEMBL17752357 | 0.79 | PDGFRB (0.44) | PDGFRBPDGFRAKITFYN | |
| SCHEMBL16296701 | 0.76 | FYN (0.50) | PDGFRBPDGFRAKITFYNHTR2C | |
| SCHEMBL16437067 | 0.75 | FFAR1 (0.46) | PDGFRBPDGFRAHTR2CPTGS1NFE2L2 | |
| SCHEMBL15202541 | 0.74 | FYN (0.51) | PDGFRBPDGFRAKITFYNHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776995-B2 | Bicyclic sulfonamide compounds as sodium channel inhibitors | AMGEN INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160137636-A1 | Bicyclic Sulfonamide Compounds as Sodium Channel Inhibitors | AMGEN INC. | 2016-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137636-A1 | Bicyclic Sulfonamide Compounds as Sodium Channel Inhibitors | SCN7A, SCN1A, SCN5A | PDGFRB 3669/4885PDGFRA 2584/4885KIT 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.