Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 20/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777807 | 0.88 | GABRA5 (0.66) | GABRA5 | |
| SCHEMBL1777091 | 0.87 | GABRA5 (0.56) | GABRA5 | |
| SCHEMBL1777320 | 0.85 | GABRA5 (0.71) | GABRA5 | |
| SCHEMBL1775952 | 0.85 | GABRA5 (0.66) | GABRA5 | |
| SCHEMBL1777512 | 0.83 | GABRA5 (0.72) | GABRA5 | |
| SCHEMBL1776328 | 0.83 | GABRA5 (0.72) | GABRA5 | |
| SCHEMBL1777696 | 0.83 | GABRA5 (0.59) | GABRA5 | |
| SCHEMBL1776414 | 0.83 | GABRA5 (0.61) | GABRA5 | |
| SCHEMBL1775339 | 0.82 | GABRA5 (0.59) | GABRA5 | |
| SCHEMBL1777224 | 0.82 | GABRA5 (0.58) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | claimed |
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | disclosed |