Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.57 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17754048 | 0.86 | CXCR4 (0.60) | CXCR4ALDH1A1KMT2ADRD4 | |
| SCHEMBL19658482 | 0.81 | ACHE (0.56) | ACHECXCR4ALDH1A1KMT2ACYP2A13 | |
| SCHEMBL19652162 | 0.78 | ACHE (0.52) | ACHECXCR4ALDH1A1KMT2AFAAH | |
| SCHEMBL14492295 | 0.76 | ACHE (0.69) | ACHECXCR4ALDH1A1KMT2ACYP2A13 | |
| SCHEMBL29767426 | 0.76 | CXCR4 (0.69) | ACHECXCR4ALDH1A1KMT2ACYP2A13 | |
| SCHEMBL12013922 | 0.74 | ACHE (1.00) | ACHECXCR4ALDH1A1KMT2ACYP2A13 | |
| SCHEMBL17754049 | 0.73 | MAPT (0.63) | ACHECXCR4ALDH1A1BCHEKDM4E | |
| SCHEMBL15933910 | 0.73 | ACHE (0.65) | ACHECXCR4ALDH1A1KMT2ACYP2A13 | |
| SCHEMBL6941873 | 0.72 | ACHE (0.73) | ACHECXCR4ALDH1A1KMT2ACYP2A13 | |
| SCHEMBL2321124 | 0.72 | KMT2A (0.67) | ACHEALDH1A1KMT2ACYP2A13LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077375-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |