Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM1A | O60341 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27046360 | 0.90 | HPGD (0.53) | ALDH1A1LMNAHPGDMEN1KMT2A | |
| SCHEMBL14290951 | 0.83 | HDAC3 (0.52) | HTT | |
| SCHEMBL764726 | 0.80 | PTGS1 (0.56) | PTGS1PTGS2HTTKDM1AMAOA | |
| SCHEMBL27846332 | 0.78 | PTGS1 (0.58) | PTGS1PTGS2HTTKDM1AMAOA | |
| SCHEMBL19658728 | 0.76 | HTT (0.67) | PTGS1PTGS2HTTALDH1A1LMNA | |
| SCHEMBL16133046 | 0.75 | PTGS1 (0.51) | PTGS1PTGS2HTTKDM1AMAOA | |
| SCHEMBL27043933 | 0.75 | PDE2A (0.47) | — | |
| SCHEMBL71414 | 0.75 | PTGS1 (0.62) | PTGS1PTGS2HTTKDM1AMAOA | |
| SCHEMBL8763413 | 0.74 | ADH1B (0.46) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14668855 | 0.74 | UGCG (0.51) | PTGS1PTGS2HTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077375-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |