Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17753815 | 0.85 | BRD4 (0.54) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17753568 | 0.83 | BRD4 (0.40) | JAK2JAK1TYK2JAK3ACHE | |
| SCHEMBL28382203 | 0.82 | FASN (0.40) | ACHEHTR4SIGMAR1 | |
| SCHEMBL17753984 | 0.79 | BRD4 (0.55) | ACHEHTR4SIGMAR1 | |
| SCHEMBL17749037 | 0.78 | LIMK2 (0.49) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL17753836 | 0.78 | BRD4 (0.53) | ACHEHTR4SIGMAR1 | |
| SCHEMBL17753987 | 0.77 | TAF1 (0.56) | ACHEHTR4SIGMAR1 | |
| SCHEMBL17753823 | 0.77 | BRD4 (0.50) | JAK2JAK1TYK2JAK3ACHE | |
| SCHEMBL17753814 | 0.74 | BRD4 (0.52) | ACHEHTR4SIGMAR1 | |
| SCHEMBL19658385 | 0.74 | ACHE (0.60) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077375-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |