Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CECR2 | Q9BXF3 | 4/20 | 0.54 |
| ▸ | TAF1 | P21675 | 4/20 | 0.54 |
| ▸ | BRD4 | O60885 | 4/20 | 0.54 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19639705 | 1.00 | CECR2 (0.54) | CECR2TAF1BRD4BRD9TP53 | |
| SCHEMBL17748995 | 1.00 | CECR2 (0.54) | CECR2TAF1BRD4BRD9TP53 | |
| SCHEMBL17753771 | 0.89 | CECR2 (0.55) | CECR2TAF1BRD4BRD9 | |
| SCHEMBL17753686 | 0.89 | BRD4 (0.52) | CECR2TAF1BRD4BRD9ALDH1A1 | |
| SCHEMBL17753665 | 0.89 | TAF1 (0.52) | CECR2TAF1BRD4BRD9PDE10A | |
| SCHEMBL17753666 | 0.89 | CECR2 (0.52) | CECR2TAF1BRD4BRD9ALDH1A1 | |
| SCHEMBL17754172 | 0.89 | BRD4 (0.52) | CECR2TAF1BRD4BRD9PDE10A | |
| SCHEMBL17753693 | 0.87 | CECR2 (0.53) | CECR2TAF1BRD4BRD9 | |
| SCHEMBL17754062 | 0.85 | CECR2 (0.51) | CECR2TAF1BRD4BRD9 | |
| SCHEMBL17753698 | 0.85 | CECR2 (0.51) | CECR2TAF1BRD4BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
| WO-2016077375-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | BRD4, BRDT, BRD3 | CECR2 184/4885TAF1 439/4885BRD4 1/4885 |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | CECR2 184/4885TAF1 439/4885BRD4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.