⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15715662 | 0.72 | — | — | |
| SCHEMBL17664457 | 0.60 | — | — | |
| Hydrochloric Acid SCHEMBL3715307 | 0.55 | — | — | |
| SCHEMBL13018065 | 0.55 | — | — | |
| SCHEMBL15810549 | 0.53 | — | — | |
| SCHEMBL18774123 | 0.51 | — | — | |
| SCHEMBL1767692 | 0.43 | — | — | |
| SCHEMBL1767793 | 0.40 | — | — | |
| SCHEMBL22366550 | 0.40 | IMPDH2 (0.42) | — | |
| SCHEMBL5519306 | 0.40 | MAPT (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472367-B2 | Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors | INCYTE INCORPORATION (US) | 2019-11-12 | — | — | US | disclosed |
| US-9988387-B2 | Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2018-06-05 | — | — | US | disclosed |
| US-9988387-B2 | Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2018-06-05 | — | — | US | disclosed |
| US-20160137650-A1 | IMIDAZO[1,2-B][1,2,4]TRIAZINES AS C-MET INHIBITORS | INCYTE CORPORATION | 2016-05-19 | — | — | US | disclosed |
| US-20160137650-A1 | IMIDAZO[1,2-B][1,2,4]TRIAZINES AS C-MET INHIBITORS | INCYTE CORPORATION | 2016-05-19 | — | — | US | disclosed |