Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | LIPC | P11150 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 2/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17754837 | 0.92 | MET (0.51) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL20215089 | 0.91 | MET (0.50) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL17754827 | 0.89 | MET (0.54) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL17754939 | 0.85 | MET (0.51) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL17754824 | 0.85 | MET (0.56) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL17754840 | 0.84 | MET (0.51) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL16367799 | 0.84 | MET (0.52) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL17754829 | 0.81 | MET (0.54) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL20215771 | 0.80 | MET (0.47) | METFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL22045729 | 0.78 | MET (0.55) | METFGFR1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988381-B2 | Five-member-heterocycle fused pyridine compounds, method of producing the same, and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2018-06-05 | — | — | US | disclosed |
| US-20160137640-A1 | FIVE-MEMBER-HETEROCYCLE FUSED PYRIDINE COMPOUNDS, METHOD OF PRODUCING THE SAME, AND USE THEREOF | SHANGHAI HAIHE PHARMACEUTICAL CO. LTD. (CN) | 2016-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137640-A1 | FIVE-MEMBER-HETEROCYCLE FUSED PYRIDINE COMPOUNDS, METHOD OF PRODUCING THE SAME, AND USE THEREOF | ABL1, JAK2, LCK | MET 213/4885FGFR1 68/4885FGFR2 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.