Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 5/20 | 0.69 |
| ▸ | TAF1 | P21675 | 3/20 | 0.53 |
| ▸ | IL2 | P60568 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.43 |
| ▸ | TNKS | O95271 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17748938 | 0.82 | BRD9 (1.00) | BRD9TAF1BRD4CECR2 | |
| SCHEMBL29874888 | 0.72 | BRD9 (0.52) | BRD9TAF1IL2MAP4K1TNKS | |
| SCHEMBL22872849 | 0.71 | PARP1 (0.65) | PRKAA1PARP1BRD4CECR2 | |
| SCHEMBL22872872 | 0.71 | BRD4 (0.52) | BRD9PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16474981 | 0.70 | AURKA (0.52) | BRD4ZAP70 | |
| SCHEMBL17756336 | 0.70 | TAF1 (0.52) | BRD9TAF1PARP1BRD4 | |
| SCHEMBL17748933 | 0.69 | TAF1 (1.00) | BRD9TAF1BRD4CECR2 | |
| SCHEMBL17756333 | 0.68 | BRD9 (0.51) | BRD9TAF1PARP1BRD4CECR2 | |
| SCHEMBL29204307 | 0.68 | MAP4K1 (0.64) | BRD9IL2MAP4K1 | |
| SCHEMBL31590691 | 0.68 | AURKA (0.37) | BRD9PARP1BRD4CECR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077380-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |