Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAF1 | P21675 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 6/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22872849 | 0.73 | PARP1 (0.65) | CLK1CLK2DYRK1AHIPK2CLK4 | |
| SCHEMBL17756333 | 0.72 | BRD9 (0.51) | TAF1BRD4BRD9PARP1 | |
| SCHEMBL17755606 | 0.70 | BRD9 (0.69) | TAF1BRD4BRD9PARP1 | |
| SCHEMBL3114982 | 0.68 | SLC18A3 (0.68) | HTR2CSLC18A3SIGMAR1HTR6NMT1 | |
| SCHEMBL17748933 | 0.68 | TAF1 (1.00) | TAF1BRD4BRD9 | |
| SCHEMBL31590691 | 0.67 | AURKA (0.37) | BRD4NOTUMBRD9PARP1 | |
| Hydrochloric Acid SCHEMBL4773172 | 0.67 | SLC18A3 (0.66) | HTR2CSLC18A3SIGMAR1HTR6NMT1 | |
| SCHEMBL31319414 | 0.65 | SLC6A4 (0.38) | HTR2CIKBKBBRD4 | |
| SCHEMBL12975654 | 0.65 | QDPR (0.49) | HTR2CSLC18A3SIGMAR1HTR6GABRA1 | |
| Hydrochloric Acid SCHEMBL2882712 | 0.64 | HTR2C (0.49) | HTR2CSLC18A3SIGMAR1HTR6GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077380-A1 | SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |