Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.59 |
| ▸ | HRH2 | P25021 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17623058 | 0.82 | HRH4 (0.54) | HRH4HRH3HRH2KDRCYP1A2 | |
| SCHEMBL2088712 | 0.81 | HRH4 (0.62) | HRH4HRH3HRH2KDRCYP1A2 | |
| SCHEMBL1774691 | 0.81 | HRH4 (0.67) | HRH4HRH3HRH2KDR | |
| SCHEMBL24319168 | 0.79 | HRH4 (0.65) | HRH4HRH3HRH2CYP1A2ALDH1A1 | |
| SCHEMBL1773934 | 0.79 | HRH4 (0.68) | HRH4HRH3HRH2KDR | |
| SCHEMBL1774487 | 0.78 | HRH4 (0.72) | HRH4HRH3HRH2KDRCYP1A2 | |
| SCHEMBL1775874 | 0.78 | HRH4 (0.64) | HRH4HRH3HRH2CYP1A2ALDH1A1 | |
| SCHEMBL25589852 | 0.78 | HRH4 (0.56) | HRH4HRH3 | |
| SCHEMBL18636724 | 0.77 | HRH4 (0.50) | HRH4HRH3HRH2KDR | |
| SCHEMBL1774533 | 0.76 | HRH4 (0.52) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| CN-101341134-B | Pyrimidine derivatives | PFIZER LTD | 2013-05-01 | — | — | CN | disclosed |
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| CN-101341134-A | Pyrimidine derivatives | PFIZER LTD (GB) | 2009-01-07 | — | — | CN | disclosed |
| US-20070185075-A1 | Pyrimidine derivatives | PFIZER LIMITED | 2007-08-09 | — | — | US | disclosed |
| US-20070185075-A1 | Pyrimidine derivatives | PFIZER LIMITED | 2007-08-09 | — | — | US | disclosed |
| US-20070185075-A1 | Pyrimidine derivatives | PFIZER LIMITED | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185075-A1 | Pyrimidine derivatives | TYMS, DPYD, TYMP | HRH4 184/4885HRH3 187/4885HRH2 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.