Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757738 | 0.90 | ACAT2 (0.38) | ACAT2 | |
| SCHEMBL17757494 | 0.89 | — | — | |
| SCHEMBL17757094 | 0.89 | — | — | |
| SCHEMBL17992106 | 0.88 | POLB (0.32) | ACAT2POLBKMT2APDE7A | |
| SCHEMBL19523291 | 0.86 | POLB (0.38) | POLBKMT2A | |
| SCHEMBL17757118 | 0.86 | ACAT2 (0.37) | ACAT2POLBKMT2APDE7A | |
| SCHEMBL17757459 | 0.85 | PDE7A (0.39) | ACAT2POLBKMT2APDE7A | |
| SCHEMBL17757244 | 0.85 | PDE7A (0.39) | ACAT2POLBKMT2APDE7A | |
| SCHEMBL17757236 | 0.84 | KMT2A (0.48) | POLBKMT2AMAPT | |
| SCHEMBL17757849 | 0.84 | CYP3A4 (0.34) | ACAT2KMT2APDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016075137-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2016-05-19 | — | — | WO | disclosed |