Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT2 | Q9BWD1 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757849 | 0.89 | CYP3A4 (0.34) | ACAT2EGFR | |
| SCHEMBL17757289 | 0.88 | ACAT2 (0.39) | ACAT2 | |
| SCHEMBL17757081 | 0.87 | EGFR (0.30) | EGFR | |
| SCHEMBL17758060 | 0.87 | STAT6 (0.32) | EGFR | |
| SCHEMBL17757304 | 0.87 | ACAT2 (0.50) | ACAT2 | |
| SCHEMBL17992064 | 0.86 | ACAT2 (0.39) | ACAT2 | |
| SCHEMBL17757720 | 0.86 | ACAT2 (0.39) | ACAT2 | |
| SCHEMBL17757282 | 0.86 | ACAT2 (0.49) | ACAT2 | |
| SCHEMBL17757723 | 0.86 | ACAT2 (0.39) | ACAT2 | |
| SCHEMBL17757738 | 0.84 | ACAT2 (0.38) | ACAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016075137-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2016-05-19 | — | — | WO | disclosed |