SCHEMBL17758015

SCHEMBL17758015

C#CCOC(OCC#C)c1cc(Oc2ccc(Cl)cc2Cl)ccc1[N+](=O)[O-]

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.51
PDE7A Q13946 2/20 0.43
TSHR P16473 1/20 0.41
MAPK1 P28482 1/20 0.41
S1PR4 O95977 3/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
TTR P02766 1/20 0.40
PPOX P50336 1/20 0.40
FFAR1 O14842 2/20 0.37
MAPT P10636 2/20 0.36
MERTK Q12866 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.36
KDM4E B2RXH2 1/20 0.35
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19625243 0.92 TDP1 (0.45) TDP1PDE7ATSHRMAPK1S1PR4
SCHEMBL10686176 0.82 TDP1 (0.63) TDP1PDE7ATSHRMAPK1S1PR4
SCHEMBL26758044 0.79 TDP1 (0.62) TDP1PDE7ATSHRMAPK1S1PR4
SCHEMBL11152276 0.76 TDP1 (0.67) TDP1PDE7ATSHRMAPK1S1PR4
SCHEMBL10851196 0.76 TDP1 (0.67) TDP1PDE7ATSHRMAPK1S1PR4
SCHEMBL10847574 0.75 TDP1 (0.65) TDP1PDE7ATSHRMAPK1S1PR4
SCHEMBL10881418 0.74 TDP1 (0.61) TDP1PDE7ATSHRMAPK1S1PR4
SCHEMBL10882415 0.73 TDP1 (0.62) TDP1PDE7ATSHRMAPK1S1PR4
SCHEMBL9332087 0.73 TDP1 (0.66) TDP1PDE7ATSHRMAPK1S1PR4
SCHEMBL27894847 0.73 TDP1 (0.62) TDP1PDE7ATSHRMAPK1S1PR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016075289-A1 BENZYLPROPARGYLETHER AS NITRIFICATION INHIBITORS BASF SE (DE) 2016-05-19 WO disclosed