Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 6/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17751673 | 0.93 | TLR2 (0.46) | TLR2MDM4TP53HDAC1HDAC2 | |
| SCHEMBL26474537 | 0.92 | MDM2 (0.46) | TLR2MDM4TP53HDAC1HDAC2 | |
| SCHEMBL19367953 | 0.88 | TLR2 (0.43) | TLR2MDM4TP53HDAC1HDAC2 | |
| SCHEMBL13049087 | 0.84 | TLR2 (0.47) | TLR2MDM4TP53MDM2 | |
| SCHEMBL31591662 | 0.84 | MDM2 (0.42) | TLR2MDM4TP53HDAC1HDAC2 | |
| SCHEMBL31591669 | 0.84 | MDM4 (0.46) | TLR2MDM4TP53MDM2 | |
| SCHEMBL18161126 | 0.83 | TLR2 (0.43) | TLR2MDM4TP53MDM2 | |
| SCHEMBL31624497 | 0.83 | HDAC1 (0.48) | TLR2HDAC1HDAC2 | |
| SCHEMBL31624368 | 0.83 | HDAC1 (0.48) | TLR2HDAC1HDAC2 | |
| SCHEMBL18161129 | 0.83 | TLR2 (0.44) | TLR2MDM4TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077518-A1 | MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-05-19 | — | — | WO | disclosed |