Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | HTR1D | P28221 | 3/20 | 0.56 |
| ▸ | HTR1B | P28222 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | NCF1 | P14598 | 5/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1776013 | 0.99 | HTR6 (0.56) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL1775825 | 0.86 | HTR6 (0.63) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL1776854 | 0.85 | HTR6 (0.64) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL1773868 | 0.85 | HTR6 (0.62) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL1776286 | 0.84 | HTR6 (0.63) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL1777254 | 0.83 | HTR6 (0.62) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL1777537 | 0.82 | HTR6 (0.61) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL1774911 | 0.80 | HTR6 (0.62) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL1776431 | 0.80 | HTR6 (0.73) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL1774985 | 0.79 | HTR6 (0.66) | HTR6HTR1AHTR1DHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |