Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.72 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1774664 | 0.99 | HTR6 (0.71) | HTR6HTR2CSCN9AHTR1ADRD2 | |
| SCHEMBL1778034 | 0.96 | HTR6 (0.67) | HTR6HTR2CSCN9AHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL1778427 | 0.95 | HTR6 (0.66) | HTR6HTR2CSCN9AHTR1ADRD2 | |
| SCHEMBL1776016 | 0.90 | HTR6 (0.74) | HTR6HTR2CHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1775327 | 0.89 | HTR6 (0.72) | HTR6HTR2CHTR1ADRD2HTR7 | |
| SCHEMBL1774802 | 0.86 | HTR6 (0.76) | HTR6HTR2CHTR1ADRD2HTR7 | |
| SCHEMBL1778549 | 0.86 | HTR6 (0.69) | HTR6HTR2CHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1774991 | 0.85 | HTR6 (0.74) | HTR6HTR2CHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1781144 | 0.85 | HTR6 (0.67) | HTR6HTR2CHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1775698 | 0.83 | HTR6 (0.78) | HTR6HTR2CHTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |