Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | GPR139 | Q6DWJ6 | 13/20 | 0.83 |
| ▸ | GAA | P10253 | 1/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17767038 | 0.91 | GPR139 (1.00) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 | |
| SCHEMBL17767090 | 0.90 | GPR139 (0.85) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 | |
| SCHEMBL17767008 | 0.90 | SMN1; SMN2 (0.81) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 | |
| SCHEMBL17767205 | 0.89 | GPR139 (1.00) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 | |
| SCHEMBL17766917 | 0.89 | GPR139 (1.00) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 | |
| SCHEMBL17769135 | 0.84 | GPR139 (0.77) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 | |
| SCHEMBL17767085 | 0.82 | GPR139 (1.00) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 | |
| SCHEMBL17767162 | 0.80 | GPR139 (0.82) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 | |
| SCHEMBL17769143 | 0.79 | GPR139 (0.71) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 | |
| SCHEMBL17767010 | 0.78 | GPR139 (1.00) | SMN1; SMN2GPR139GAAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221298-A1 | 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINES AS MODULATORS OF GPR139 | Takeda Pharmaceutical Company Limited (JP) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016081736-A1 | 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINES AS MODULATORS OF GPR139 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-05-26 | — | — | WO | disclosed |