Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | IDH2 | P48735 | 5/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | LPL | P06858 | 1/20 | 0.38 |
| ▸ | LIPC | P11150 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365675 | 1.00 | KDM4E (0.42) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17618904 | 1.00 | KDM4E (0.42) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17618905 | 0.95 | PHGDH (0.41) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL16238412 | 0.95 | PHGDH (0.41) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17618363 | 0.91 | MPL (0.42) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL17618361 | 0.91 | ALOX15 (0.43) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL16238662 | 0.91 | TRPV1 (0.39) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL16238017 | 0.91 | TRPV1 (0.39) | KDM4ELMNAHSD17B10USP2ALOX15 | |
| SCHEMBL16775953 | 0.90 | TRPV1 (0.44) | KDM4ELMNAHSD17B10PHGDHTRPV1 | |
| SCHEMBL17618369 | 0.90 | IDH2 (0.39) | KDM4ELMNAHSD17B10USP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221322-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079711-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016079711-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |