Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | BCR | P11274 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 7/20 | 0.37 |
| ▸ | HTR2C | P28335 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17778627 | 1.00 | GRM5 (0.43) | GRM5BTKABL1BCRALDH1A1 | |
| SCHEMBL17778649 | 0.95 | GRM5 (0.41) | GRM5ABL1BCRPIM1HTR2A | |
| SCHEMBL19689690 | 0.95 | GRM5 (0.41) | GRM5ABL1BCRPIM1HTR2A | |
| SCHEMBL20733261 | 0.89 | KMT2A (0.42) | BTKABL1BCRALDH1A1MAPT | |
| SCHEMBL16776482 | 0.89 | ALDH1A1 (0.42) | GRM5BTKABL1BCRALDH1A1 | |
| SCHEMBL16754430 | 0.88 | HTR2A (0.39) | ALDH1A1HTR2AHTR2CKMT2A | |
| SCHEMBL17778603 | 0.85 | ALDH1A1 (0.40) | GRM5BTKALDH1A1MAPTHTR2A | |
| SCHEMBL17778469 | 0.84 | ALDH1A1 (0.42) | BTKALDH1A1MAPTHTR2AHTR2C | |
| SCHEMBL19689778 | 0.84 | HTR2C (0.41) | ALDH1A1MAPTHTR2AHTR2C | |
| SCHEMBL17778392 | 0.84 | HTR2A (0.37) | ALDH1A1HTR2AHTR2CPORCN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221322-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079711-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |