Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 4/20 | 0.32 |
| ▸ | AXL | P30530 | 4/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | CBLB | Q13191 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17770276 | 1.00 | MAP3K5 (0.32) | MAP3K5AXLPIK3C3AKT1CNR2 | |
| SCHEMBL17770048 | 1.00 | MAP3K5 (0.32) | MAP3K5AXLPIK3C3AKT1CNR2 | |
| SCHEMBL17770272 | 1.00 | MAP3K5 (0.32) | MAP3K5AXLPIK3C3AKT1CNR2 | |
| SCHEMBL17770061 | 0.92 | DYRK1A (0.38) | CNR2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL17770057 | 0.92 | DYRK1A (0.38) | CNR2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19736182 | 0.92 | DYRK1A (0.38) | CNR2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19714534 | 0.88 | NTRK1 (0.37) | AXLCNR2CBLB | |
| SCHEMBL19714533 | 0.88 | NTRK1 (0.37) | AXLCNR2CBLB | |
| SCHEMBL20720935 | 0.88 | GSK3B (0.37) | AKT1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL17778546 | 0.88 | GSK3B (0.37) | AKT1PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079710-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |