Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 9/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19714533 | 1.00 | NTRK1 (0.37) | NTRK1MAP4K1AXLGPR6ACACB | |
| SCHEMBL19714324 | 0.92 | RPS6KA3 (0.37) | — | |
| SCHEMBL19714243 | 0.92 | AXL (0.33) | NTRK1MAP4K1AXLCNR2CBLB | |
| SCHEMBL19714017 | 0.92 | RPS6KA3 (0.37) | — | |
| SCHEMBL19714239 | 0.92 | AXL (0.33) | NTRK1MAP4K1AXLCNR2CBLB | |
| SCHEMBL22239765 | 0.92 | AXL (0.33) | NTRK1MAP4K1AXLCNR2CBLB | |
| SCHEMBL17769861 | 0.91 | NTRK1 (0.33) | NTRK1MAP4K1AXLACACBCNR2 | |
| SCHEMBL17777016 | 0.91 | AXL (0.33) | NTRK1MAP4K1AXLACACBCNR2 | |
| SCHEMBL17770116 | 0.91 | AXL (0.33) | NTRK1MAP4K1AXLACACBCNR2 | |
| SCHEMBL17770122 | 0.91 | AXL (0.33) | NTRK1MAP4K1AXLACACBCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |
| US-10072011-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2018-09-11 | — | — | US | disclosed |
| US-20170362234-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10072011-B2 | Substituted bridged urea analogs as sirtuin modulators | SIRT1, SIRT3, SIRT2 | NTRK1 4760/4885MAP4K1 1855/4885AXL 542/4885 |
| US-20170362234-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | NTRK1 4760/4885MAP4K1 1855/4885AXL 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.