Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 3/20 | 0.34 |
| ▸ | BTD | P43251 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17770563 | 0.90 | PRMT3 (0.35) | PRMT3VNN1BTDHPGDPTK2 | |
| SCHEMBL1567457 | 0.83 | PRMT3 (0.35) | PRMT3VNN1BTDHPGD | |
| SCHEMBL1567451 | 0.80 | HPGD (0.34) | PRMT3VNN1BTDHPGD | |
| SCHEMBL25429370 | 0.75 | PRMT3 (0.36) | PRMT3HPGD | |
| SCHEMBL17770564 | 0.74 | PRMT3 (0.33) | PRMT3 | |
| SCHEMBL17261540 | 0.72 | HCAR2 (0.33) | — | |
| SCHEMBL30252102 | 0.72 | HCAR2 (0.33) | — | |
| SCHEMBL27082168 | 0.71 | KMT2A (0.38) | HPGD | |
| SCHEMBL13102518 | 0.70 | CLK4 (0.41) | VNN1 | |
| SCHEMBL1567452 | 0.70 | FGFR2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3220912-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | Pharmacyclics LLC (US) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016081460-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | PHARMACYCLICS LLC (US) | 2016-05-26 | — | — | WO | disclosed |