Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12528394 | 1.00 | MAPT (0.41) | MAPTCYP3A4TSHRTDP1APEX1 | |
| Hydrochloric Acid SCHEMBL12495233 | 0.98 | MAPT (0.39) | MAPTCYP3A4TSHRTDP1APEX1 | |
| Hydrochloric Acid SCHEMBL12495232 | 0.98 | MAPT (0.39) | MAPTCYP3A4TSHRTDP1APEX1 | |
| SCHEMBL17770870 | 0.98 | MAPT (0.42) | MAPTCYP3A4TSHRTDP1APEX1 | |
| SCHEMBL12527920 | 0.98 | MAPT (0.42) | MAPTCYP3A4TSHRTDP1APEX1 | |
| SCHEMBL31228098 | 0.94 | CYP3A4 (0.42) | MAPTCYP3A4TSHRTDP1APEX1 | |
| SCHEMBL25873180 | 0.94 | CYP3A4 (0.42) | MAPTCYP3A4TSHRTDP1APEX1 | |
| SCHEMBL31291962 | 0.88 | CYP3A4 (0.48) | MAPTCYP3A4TSHRTDP1APEX1 | |
| SCHEMBL4654654 | 0.85 | OPRM1 (0.41) | MAPTCYP3A4TSHRTDP1APEX1 | |
| SCHEMBL4655669 | 0.85 | OPRM1 (0.37) | MAPTCYP3A4TSHRTDP1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9346852-B2 | Substituted adipic acid amides and uses thereof | BRISTOL-MYERS SCUIBB COMPANY (US) | 2016-05-24 | — | — | US | disclosed |
| US-9346852-B2 | Substituted adipic acid amides and uses thereof | BRISTOL-MYERS SCUIBB COMPANY (US) | 2016-05-24 | — | — | US | disclosed |