Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 10/20 | 0.35 |
| ▸ | KDM5A | P29375 | 6/20 | 0.35 |
| ▸ | KDM5C | P41229 | 5/20 | 0.35 |
| ▸ | KDM4A | O75164 | 3/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.33 |
| ▸ | KDM4B | O94953 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NMT2 | O60551 | 1/20 | 0.32 |
| ▸ | NMT1 | P30419 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16310762 | 0.84 | KDM5B (0.39) | KDM5BKDM5AKDM5CKDM4AKDM2B | |
| SCHEMBL16291432 | 0.84 | KDM5B (0.39) | KDM5BKDM5AKDM5CKDM4AKDM2B | |
| SCHEMBL19574692 | 0.78 | KDM5B (0.41) | KDM5BKDM5AKDM5CKDM4AKDM2B | |
| SCHEMBL15638915 | 0.72 | KDM5B (0.56) | KDM5BKDM5AKDM5CKDM4AKDM2B | |
| SCHEMBL16291504 | 0.71 | KDM5B (0.46) | KDM5BKDM5AKDM5CKDM4AKDM2B | |
| SCHEMBL17144520 | 0.68 | TRPV3 (0.50) | KDM5BKDM5AKDM5CKDM4AKDM2B | |
| SCHEMBL17144518 | 0.68 | TRPV3 (0.50) | KDM5BKDM5AKDM5CKDM4AKDM2B | |
| SCHEMBL24015863 | 0.67 | FNTA (0.43) | NAMPTKDM4E | |
| SCHEMBL17144521 | 0.65 | KDM5B (0.45) | KDM5BKDM5AKDM5CKDM4AKDM2B | |
| Acetic Acid SCHEMBL2943155 | 0.65 | FNTA (0.47) | NAMPTOPRK1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2903968-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2016-12-07 | — | — | EP | disclosed |
| EP-3023415-A1 | INHIBITORS OF HISTONE DEMETHYLASES | Epitherapeutics ApS (DK) | 2016-05-25 | — | — | EP | disclosed |