Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.69 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.69 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.69 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.56 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.56 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.56 |
| ▸ | AMD1 | P17707 | 2/20 | 0.55 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.53 |
| ▸ | AHCY | P23526 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17108373 | 1.00 | PI4KA (0.69) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL14703570 | 0.94 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL803939 | 0.94 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL14703568 | 0.94 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395521 | 0.94 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9940483 | 0.90 | PI4KA (0.74) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970645 | 0.90 | PI4KA (0.74) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9940478 | 0.90 | PI4KA (0.74) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL17109960 | 0.88 | PI4KA (0.66) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL13664461 | 0.88 | PI4KA (0.62) | PI4KAPI4K2BPI4K2API4KBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9535067-B2 | DOT1L probes | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-01-03 | — | — | US | disclosed |
| US-20160146817-A1 | DOT1L PROBES | DANA-FARBER CANCER INSTITUTE, INC. | 2016-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160146817-A1 | DOT1L PROBES | DOT1L, ASH1L, CHD1L | PI4KA 1939/4885PI4K2B 2378/4885PI4K2A 2656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.