Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.71 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.71 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.71 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.57 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.57 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.57 |
| ▸ | AMD1 | P17707 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.50 |
| ▸ | AHCY | P23526 | 1/20 | 0.48 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15395521 | 1.00 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL14703568 | 1.00 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL14703570 | 1.00 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL17108373 | 0.94 | PI4KA (0.69) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL17773142 | 0.94 | PI4KA (0.69) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9940478 | 0.92 | PI4KA (0.74) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970645 | 0.92 | PI4KA (0.74) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9940483 | 0.92 | PI4KA (0.74) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9104337 | 0.88 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9940465 | 0.88 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9949999-B2 | Inhibitors of human EZH2, and methods of use thereof | Epizyme, Inc. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170065628-A1 | Inhibitors of Human EZH2, and Methods of Use Thereof | Epizyme, Inc. | 2017-03-09 | — | — | US | disclosed |
| US-20170065600-A1 | INHIBITORS OF HUMAN EZH2, AND METHODS OF USE THEREOF | Epizyme, Inc. | 2017-03-09 | — | — | US | disclosed |
| US-9333217-B2 | Inhibitors of human EZH2, and methods of use thereof | Epizyme, Inc. (US) | 2016-05-10 | — | — | US | disclosed |
| US-20150141362-A1 | Inhibitors of Human EZH2, and Methods of Use Thereof | Epizyme, Inc. | 2015-05-21 | — | — | US | disclosed |
| US-8895245-B2 | Inhibitors of human EZH2 and methods of use thereof | Epizyme, Inc. (US) | 2014-11-25 | — | — | US | disclosed |
| US-8691507-B2 | Inhibitors of human EZH2 and methods of use thereof | Epizyme, Inc. (US) | 2014-04-08 | — | — | US | disclosed |
| US-20130303555-A1 | Inhibitors of Human EZH2 and Methods of Use Thereof | Epizyme, Inc. | 2013-11-14 | — | — | US | disclosed |
| US-20120071418-A1 | Inhibitors of Human EZH2 and Methods of Use Thereof | Epizyme, Inc. (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303555-A1 | Inhibitors of Human EZH2 and Methods of Use Thereof | EZH2, DOT1L, PRDM7 | PI4KA 3382/4885PI4K2B 3533/4885PI4K2A 3708/4885 |
| US-20120071418-A1 | Inhibitors of Human EZH2 and Methods of Use Thereof | EZH2, DOT1L, PRDM7 | PI4KA 3240/4885PI4K2B 3228/4885PI4K2A 3574/4885 |
| US-20170065600-A1 | INHIBITORS OF HUMAN EZH2, AND METHODS OF USE THEREOF | EZH2, DOT1L, PRDM7 | PI4KA 3144/4885PI4K2B 3147/4885PI4K2A 3473/4885 |
| US-20170065628-A1 | Inhibitors of Human EZH2, and Methods of Use Thereof | EZH2, DOT1L, PRDM7 | PI4KA 3144/4885PI4K2B 3147/4885PI4K2A 3473/4885 |
| US-20150141362-A1 | Inhibitors of Human EZH2, and Methods of Use Thereof | EZH2, DOT1L, PRDM7 | PI4KA 3144/4885PI4K2B 3147/4885PI4K2A 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.