Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 15/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17770070 | 1.00 | PDE2A (0.35) | PDE2AKDM5AJAK2NTRK1AXL | |
| SCHEMBL17770066 | 1.00 | PDE2A (0.35) | PDE2AKDM5AJAK2NTRK1AXL | |
| SCHEMBL17769333 | 0.94 | PDE2A (0.36) | PDE2AJAK2NTRK1 | |
| SCHEMBL20721004 | 0.94 | PDE2A (0.36) | PDE2AJAK2NTRK1 | |
| SCHEMBL17769334 | 0.94 | PDE2A (0.36) | PDE2AJAK2NTRK1 | |
| SCHEMBL20721005 | 0.94 | PDE2A (0.36) | PDE2AJAK2NTRK1 | |
| SCHEMBL19736198 | 0.89 | KDM4E (0.38) | PDE2AKDM5A | |
| SCHEMBL17770532 | 0.83 | NAPEPLD (0.36) | PDE2AKDM5AJAK2AXL | |
| SCHEMBL17776953 | 0.83 | NAPEPLD (0.36) | PDE2AKDM5AJAK2AXL | |
| SCHEMBL20550574 | 0.82 | AXL (0.36) | JAK2NTRK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |
| WO-2016079710-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |