NAPEPLD — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1271645	0.61	19/20
SCHEMBL2128617	0.50	16/20
SCHEMBL1733450	0.61	14/20
SCHEMBL2572680	0.50	13/20
SCHEMBL2128423	0.53	12/20
SCHEMBL2128718	0.51	12/20
SCHEMBL788303	0.39	9/20
SCHEMBL806202	0.44	8/20
Hydrochloric Acid (SCHEMBL2178300)	0.44	7/20
SCHEMBL1709597	0.34	7/20
SCHEMBL1880231	0.53	6/20
SCHEMBL1123412	0.68	5/20
SCHEMBL2129135	0.48	5/20
SCHEMBL2130234	0.48	5/20
SCHEMBL2129755	0.48	5/20
SCHEMBL1271927	0.44	5/20
SCHEMBL493155	0.39	5/20
SCHEMBL2012646	0.37	5/20
SCHEMBL2128993	0.52	4/20
SCHEMBL241043	0.52	4/20

Clinical trials — most relevant to NAPEPLD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL)	PHASE4	COMPLETED
Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain	PHASE4	COMPLETED
Effectiveness of Vitamin D in Primary Dysmenorrhoea	PHASE3	COMPLETED
Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty	PHASE1/PHASE2	NOT_YET_RECRUITING
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions	PHASE2	RECRUITING
Anti-CD38 Antibody Treating APS With Thrombocytopenia	PHASE2	RECRUITING
IN10018 in Combination With Pegylated Liposomal Doxorubicin (PLD) vs. Placebo in Combination With PLD for the Treatment of Platinum-resistant Recurrent Ovarian Cancer	PHASE2	RECRUITING
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients	nan	COMPLETED
Oatmeal Effect on N-acyl-phosphatidylethanolamines	nan	COMPLETED
Choline to Improve Malnutrition and Enhance Cognition	nan	RECRUITING
Palmitoylethanolamide in Ulcerative Colitis	nan	NOT_YET_RECRUITING
Efficacy Study of Vayarin in Children With Autism and Comorbid Attention Deficit Hyperactivity Disorder (ADHD)	nan	COMPLETED
Plasma Free Fatty Acids Profile As A Diagnostic Tool For Acute Ischemic Stroke	nan	COMPLETED
Omega-3 Fatty Acid in Treating Pain in Patients With Breast or Ovarian Cancer Receiving Paclitaxel	nan	COMPLETED
Choline Uptake Study	nan	COMPLETED
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease.	nan	UNKNOWN
Mucomyst for Hepatitis C	nan	SUSPENDED
Platelet-activating Factor Acetylhydrolase (Paf-ah) Gene Expression	nan	COMPLETED
Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease	nan	RECRUITING
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.	nan	COMPLETED
NETs: Protection or Harm in Neonatal Inflammation or Infection	nan	RECRUITING
Positron Emission Tomography (PET) to Study Brain Signaling	nan	COMPLETED
The Role of Human Milk in Development of Breast Fed Child's Intestinal Microbiota	nan	COMPLETED
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).	nan	RECRUITING
Phospholipid Hypothesis of Depression: From Molecular Biology, Neuroimaging to Behaviour	nan	COMPLETED
Role of PLA2G1B During HIV Infection	nan	UNKNOWN
The Association Between LPCAT1 Genetic Polymorphism and Stress Biomarkers in Neonatal Respiratory Distress Syndrome	nan	UNKNOWN
Effect of a Black Garlic Extract on Cholesterol LDL Levels	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NAPEPLD binder may also engage these)

Protein	Name	Similarity
Q5RCU3	—	1.000	Q5RCU3 →
Q8BH82	—	1.000	Q8BH82 →
Q58CN9	—	0.999	Q58CN9 →
Q769K2	—	0.998	Q769K2 →
Q965X9	—	0.990	Q965X9 →
Q965X7	—	0.989	Q965X7 →
Q02883	—	0.982	Q02883 →
A0A179HLJ8	—	0.981	A0A179HLJ8 →
P11035	—	0.979	P11035 →
P11832	—	0.979	P11832 →
Q18161	—	0.978	Q18161 →
P39867	—	0.978	P39867 →
PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	0.977	landscape →
P11605	—	0.977	P11605 →
O74430	—	0.976	O74430 →
B1WBP0	—	0.976	B1WBP0 →
P23312	—	0.976	P23312 →
P39869	—	0.976	P39869 →
P78875	—	0.976	P78875 →
Q29RY4	—	0.976	Q29RY4 →
P70265	—	0.976	P70265 →
G5EDL5	—	0.976	G5EDL5 →
Q59P50	—	0.976	Q59P50 →
Q15777	—	0.976	Q15777 →
Q9JJH5	—	0.976	Q9JJH5 →
Q05549	—	0.975	Q05549 →
P49050	—	0.975	P49050 →
Q4R8B6	—	0.975	Q4R8B6 →
P27783	—	0.975	P27783 →
Q8MKW7	—	0.975	Q8MKW7 →